DUS4L

Across TCGA pan-cancer cohorts, DUS4L RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of DUS4L’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DUS4L RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DUS4L is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LUAD, HNSC, and BLCA are the cancer types where DUS4L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DUS4L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	+1.255	<.001	11	view →
HNSC	Male	III,IV	+0.898	<.001	11	view →
BLCA	Female	III,IV	+0.867	<.001	11	view →
COAD	Male	III,IV	+1.017	<.001	10	view →
KIRP	All	II,III,IV	+0.485	.001	10	view →
LIHC	Male	All	+0.856	<.001	9	view →
STAD	Male	II,III,IV	+0.759	<.001	9	view →
THCA	Male	III,IV	−0.427	<.001	9	view →
LUSC	Male	II,III,IV	+1.048	<.001	8	view →
READ	All	III,IV	+1.080	<.001	7	view →
BRCA	All	II,III,IV	+0.451	<.001	6	view →
CHOL	Male	All	+1.493	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

DUS4L–LUAD

Open the LUAD breakdown →