DUS4L

Across TCGA pan-cancer cohorts, DUS4L RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DUS4L data layer compared with 7 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher DUS4L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DUS4L expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

KICH, UVM, and UCS are the cancer types where DUS4L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Quartile	All	0.586	1.000	.001	62	view →
UVM	DFS	Tertile	II,III,IV	0.324	0.753	.003	52	view →
UCS	DFS	Quartile	II,III,IV	0.615	0.164	.001	44	view →
LGG	OS	Tertile	All	0.686	0.886	<.001	36	view →
SKCM	OS	Median	III,IV	0.485	0.274	.006	25	view →
BLCA	DFS	Median	III,IV	0.380	0.233	.010	25	view →
CESC	DFS	Median	IV	0.268	0.727	<.001	24	view →
KIRC	DFS	Tertile	All	0.695	0.464	.005	24	view →
LIHC	DFS	Median	All	0.476	0.603	.005	21	view →
KIRP	DFS	Quartile	IV	0.162	0.485	.017	20	view →
THCA	OS	Quartile	II,III,IV	0.471	0.849	.002	16	view →
READ	OS	Quartile	II,III,IV	0.861	0.299	.007	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DUS4L–KICH (DFS)

Open the KICH breakdown →