DUS2

Across TCGA patient cohorts, DUS2 mutation is significantly associated with the RNA expression of many other genes, with 932 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUS2-associated genes across cancer lineages are RN7SL248P, KRTAP6-2, and LINC00373. Each is linked with DUS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DUS2-to-partner and partner-to-DUS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by DUS2-low versus DUS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUS2→partner) and Y-score (partner→DUS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.072	+3.500	<.001	.002	3	2
BLCA	KRTAP6-2 →	+0.162	+6.618	<.001	.001	3	2
HNSC	LINC00373 →	+0.157	+5.069	<.001	.008	3	2
HNSC	MIR4655 →	+0.498	+5.182	.001	.007	3	2
UCEC	RNU6ATAC35P →	+0.446	+3.242	<.001	.008	3	2
UCEC	RPS10P21 →	+0.315	+2.717	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 932 associations by consensus.

RN7SL248P by DUS2 expression — UCEC

Explore this box plot interactively →