DUOX1

Across TCGA patient cohorts, DUOX1 mutation is significantly associated with the RNA expression of many other genes, with 5,492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DUOX1-associated genes across cancer lineages are PHF5A, TSPY26P, and RNU4-58P. Each is linked with DUOX1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DUOX1-to-partner and partner-to-DUOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by DUOX1-low versus DUOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DUOX1→partner) and Y-score (partner→DUOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.406	+2.256	<.001	<.001	3	4
STAD	TSPY26P →	-0.802	-3.421	.001	.005	3	4
LAML	RNU4-58P →	+0.492	+5.135	<.001	.007	3	3
COAD	SENP3-EIF4A1 →	+0.205	+2.877	<.001	.001	3	3
CESC	RNU6-709P →	+0.337	+7.174	<.001	<.001	3	3
UCEC	AURKB →	+0.427	+1.874	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,492 associations by consensus.

PHF5A by DUOX1 expression — UCEC

Explore this box plot interactively →