DTX2

Across TCGA cell cohorts, DTX2 mutation is significantly associated with the RNA expression of many other genes, with 579 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DTX2-associated genes across cancer lineages are CLEC1B, KRTAP13-2, and OR4F5. Each is linked with DTX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DTX2-to-partner and partner-to-DTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC1B grouped by DTX2-low versus DTX2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTX2→partner) and Y-score (partner→DTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CLEC1B →	+0.048	+5.029	<.001	.006	3	1
LUNG_SCLC	KRTAP13-2 →	+0.032	+5.029	<.001	.006	3	1
LUNG_SCLC	OR4F5 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	OR13F1 →	+0.025	+5.029	<.001	.006	3	1
LUNG_SCLC	IFNA2 →	+0.022	+5.029	<.001	.006	3	1
LUNG_SCLC	IFNA1 →	+0.177	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 579 associations by consensus.

CLEC1B by DTX2 expression — LUNG_SCLC

Explore this box plot interactively →