DTNB

Across TCGA cell cohorts, DTNB mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DTNB-associated genes across cancer lineages are TGM6, DEFB108B, and SERPINA4. Each is linked with DTNB in more than 1 cancer types. Because this analysis shows association rather than direction, both DTNB-to-partner and partner-to-DTNB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TGM6 grouped by DTNB-low versus DTNB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DTNB→partner) and Y-score (partner→DTNB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TGM6 →	+0.022	+5.569	<.001	.001	3	2
BONE	DEFB108B →	+0.046	+5.169	<.001	.004	3	1
BLOOD_Myeloma	SERPINA4 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Myeloma	SERPINA7 →	+0.459	+4.807	<.001	.006	3	1
BLOOD_Myeloma	FSHB →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	C1orf158 →	+0.053	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

TGM6 by DTNB expression — BLOOD_Leukemia

Explore this box plot interactively →