DTNB

Across TCGA pan-cancer cohorts, DTNB RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DTNB’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DTNB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DTNB is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

COAD, BLCA, and KIRC are the cancer types where DTNB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DTNB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.678	<.001	11	view →
BLCA	All	III,IV	+1.171	<.001	11	view →
KIRC	Male	II,III,IV	−0.600	<.001	10	view →
THCA	Male	III,IV	−0.828	<.001	9	view →
LIHC	All	II,III,IV	+0.925	<.001	8	view →
UCEC	All	III,IV	+1.537	<.001	6	view →
CHOL	All	All	+1.075	<.001	5	view →
LUSC	Female	All	+0.984	<.001	5	view →
READ	All	All	+0.788	.002	5	view →
STAD	All	All	+0.596	.002	5	view →
KICH	All	All	−0.513	<.001	5	view →
PRAD	All	All	+0.253	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DTNB–COAD

Open the COAD breakdown →