DSN1

Across TCGA patient cohorts, DSN1 mutation is significantly associated with the RNA expression of many other genes, with 1,230 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSN1-associated genes across cancer lineages are RNA5SP420, LINC02854, and CDRT15P7. Each is linked with DSN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DSN1-to-partner and partner-to-DSN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP420 grouped by DSN1-low versus DSN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSN1→partner) and Y-score (partner→DSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP420 →	+0.424	+2.092	.006	.007	3	3
CESC	LINC02854 →	+0.086	+7.584	<.001	<.001	3	2
CESC	CDRT15P7 →	+0.078	+5.669	<.001	.003	3	2
CESC	RN7SL261P →	+0.123	+5.010	.006	.009	3	2
BRCA	ZNF519P4 →	+0.390	+5.070	<.001	.008	3	2
LUAD	CNN2P11 →	+0.409	+3.424	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,230 associations by consensus.

RNA5SP420 by DSN1 expression — UCEC

Explore this box plot interactively →