DSN1

Across TCGA pan-cancer cohorts, DSN1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DSN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DSN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DSN1 is over-expressed in tumor.

HNSC, BLCA, and KIRP are the cancer types where DSN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DSN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.396	<.001	12	view →
BLCA	Female	III,IV	+1.365	<.001	11	view →
KIRP	All	II,III,IV	+1.001	<.001	11	view →
LUAD	Male	All	+0.934	<.001	11	view →
KIRC	Male	IV	+0.842	<.001	11	view →
STAD	Female	All	+1.757	<.001	10	view →
COAD	Male	All	+1.325	<.001	10	view →
LIHC	Female	III,IV	+1.988	<.001	9	view →
LUSC	Female	All	+1.487	<.001	7	view →
READ	All	All	+0.996	<.001	7	view →
BRCA	All	III,IV	+1.263	<.001	6	view →
UCEC	All	II,III,IV	+1.170	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DSN1–HNSC

Open the HNSC breakdown →