DSN1

Across TCGA pan-cancer cohorts, DSN1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated DSN1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DSN1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DSN1 expression acts as an unfavorable survival marker, although some lineages such as UCS and COAD show a favorable association.

MESO, ACC, and UVM are the cancer types where DSN1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.379	0.697	<.001	135	view →
ACC	DFS	Median	All	0.382	0.781	<.001	112	view →
UVM	DFS	Tertile	All	0.274	0.790	<.001	94	view →
LIHC	DFS	Tertile	All	0.440	0.634	<.001	71	view →
LGG	DFS	Median	All	0.640	0.837	<.001	54	view →
UCS	OS	Median	IV	0.817	0.302	.002	40	view →
KIRC	DFS	Tertile	IV	0.142	0.486	.001	36	view →
UCEC	DFS	Tertile	All	0.771	0.895	<.001	32	view →
COAD	OS	Median	IV	0.672	0.392	.013	31	view →
READ	DFS	Quartile	II,III,IV	0.931	0.264	.001	30	view →
KIRP	DFS	Quartile	All	0.732	0.915	.002	28	view →
KICH	OS	Tertile	II,III,IV	0.580	1.000	.022	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

DSN1–MESO (OS)

Open the MESO breakdown →