DSN1

Across TCGA patient cohorts, DSN1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DSN1-associated genes across cancer lineages are p62 Lck ligand, 14-3-3_beta, and EGFR_pY1068. Each is linked with DSN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSN1-to-partner and partner-to-DSN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by DSN1-low versus DSN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSN1→partner) and Y-score (partner→DSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.531	+2.710	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.131	-3.432	.002	.005	3	1
UCEC	EGFR_pY1068 →	-0.286	-3.321	.007	.009	3	1
UCEC	ER-alpha_pS118 →	-0.354	-3.321	.020	.010	3	1
UCEC	ACC1 →	+0.422	+1.700	.006	.044	3	1
UCEC	IRS1 →	-0.238	-3.169	.006	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

p62 Lck ligand by DSN1 expression — UCEC

Explore this box plot interactively →