DSN1

Across TCGA cell cohorts, DSN1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DSN1-associated genes across cancer lineages are C14orf177, TEX43, and CCDC105. Each is linked with DSN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DSN1-to-partner and partner-to-DSN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf177 grouped by DSN1-low versus DSN1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DSN1→partner) and Y-score (partner→DSN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C14orf177 →	+0.076	+4.922	<.001	.009	3	1
BLOOD_Leukemia	TEX43 →	+0.141	+5.969	<.001	.001	3	1
LUNG_NSCLC_LUAD	CCDC105 →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	PYDC2 →	+0.256	+6.266	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C14orf177 by DSN1 expression — BLOOD_Leukemia

Explore this box plot interactively →