DSCAS

Across TCGA patient cohorts, DSCAS RNA expression is significantly associated with the protein abundance of many other proteins, with 9,399 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DSCAS-associated proteins across cancer lineages are DSC2, TMEM119, and DSG2. Each is linked with DSCAS in more than 5 cancer types. Because this analysis shows association rather than direction, both DSCAS-to-partner and partner-to-DSCAS results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DSCAS versus DSC2 in LSCC, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DSCAS→partner) and Y-score (partner→DSCAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DSC2 →	+0.972	+0.354	<.001	<.001	3	6
HNSC	TMEM119 →	-0.599	-0.609	.002	.002	3	3
LSCC	DSG2 →	+0.461	+0.261	<.001	<.001	3	3
HNSC	EPPK1_T34 →	+0.925	+0.784	<.001	<.001	3	3
UCEC	LXN_S41 →	-0.554	-0.595	.006	.009	3	3
COAD	BSG →	+0.276	+0.168	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,399 associations by consensus.

DSCAS vs DSC2 — LSCC

Explore this scatter interactively →