DSCAS

Across TCGA pan-cancer cohorts, DSCAS RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated DSCAS data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher DSCAS RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated DSCAS expression acts as an unfavorable survival marker, although some lineages such as UVM and PAAD show a favorable association.

UVM, PAAD, and SKCM are the cancer types where DSCAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	1.000	0.665	.013	45	view →
PAAD	DFS	Tertile	All	0.560	0.340	.010	43	view →
SKCM	OS	Tertile	All	0.854	0.760	.007	39	view →
BLCA	OS	Median	III,IV	0.294	0.587	<.001	27	view →
MESO	OS	Tertile	All	0.268	0.459	.015	27	view →
THCA	DFS	Quartile	IV	0.437	0.910	.002	26	view →
ACC	DFS	Tertile	IV	0.012	0.310	.002	18	view →
DLBC	OS	Tertile	All	0.684	0.936	.014	15	view →
HNSC	OS	Tertile	III,IV	0.476	0.310	.013	15	view →
KIRP	OS	Quartile	II,III,IV	0.649	0.356	.014	13	view →
KIRC	DFS	Median	All	0.763	0.849	.012	11	view →
KICH	OS	Median	III,IV	0.556	1.000	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

DSCAS–UVM (DFS)

Open the UVM breakdown →