DSCAS

Across TCGA pan-cancer cohorts, DSCAS RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DSCAS’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where DSCAS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DSCAS is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

STAD, BRCA, and KIRC are the cancer types where DSCAS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DSCAS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.267	<.001	7	view →
BRCA	All	All	−0.430	<.001	6	view →
KIRC	All	All	+0.183	.001	6	view →
LUSC	All	All	+0.234	<.001	4	view →
LUAD	All	All	+0.216	<.001	3	view →
READ	Female	All	+0.488	.003	2	view →
KIRP	All	IV	+0.387	.049	2	view →
LIHC	Male	All	+0.336	<.001	2	view →
PRAD	All	All	+0.285	.001	2	view →
KICH	All	All	−0.197	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DSCAS–STAD

Open the STAD breakdown →