DRC7

Across TCGA patient cohorts, DRC7 mutation is significantly associated with the RNA expression of many other genes, with 4,133 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DRC7-associated genes across cancer lineages are C1orf174, ING2, and UQCRH. Each is linked with DRC7 in more than 3 cancer types. Because this analysis shows association rather than direction, both DRC7-to-partner and partner-to-DRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf174 grouped by DRC7-low versus DRC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DRC7→partner) and Y-score (partner→DRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C1orf174 →	+0.426	+2.628	<.001	<.001	3	4
UCEC	ING2 →	+0.373	+2.151	.002	.002	3	4
UCEC	UQCRH →	+0.699	+3.939	.003	<.001	3	4
UCEC	DEPDC1 →	+0.601	+1.711	.001	.001	3	4
UCEC	DBF4 →	+0.612	+2.557	<.001	<.001	3	4
UCEC	GPN3 →	+0.438	+2.523	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,133 associations by consensus.

C1orf174 by DRC7 expression — UCEC

Explore this box plot interactively →