DRC7

Across TCGA pan-cancer cohorts, DRC7 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated DRC7 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DRC7 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DRC7 expression acts as an unfavorable survival marker, although some lineages such as KIRP and READ show a favorable association.

KIRC, KIRP, and LGG are the cancer types where DRC7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.529	0.692	<.001	77	view →
KIRP	DFS	Tertile	All	0.955	0.832	.001	69	view →
LGG	DFS	Median	All	0.290	0.481	<.001	48	view →
COAD	DFS	Quartile	III,IV	0.198	0.735	<.001	36	view →
READ	OS	Median	IV	1.000	0.677	.008	15	view →
CHOL	OS	Median	All	0.876	0.161	<.001	15	view →
THYM	OS	Tertile	All	1.000	0.540	.001	15	view →
CESC	OS	Tertile	IV	0.672	0.143	.013	12	view →
BRCA	OS	Tertile	All	0.642	0.502	.020	9	view →
STAD	OS	Quartile	II,III,IV	0.612	0.744	.028	8	view →
PAAD	DFS	Tertile	All	0.511	0.283	.027	7	view →
SKCM	DFS	Median	IV	0.763	0.187	.006	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

DRC7–KIRC (OS)

Open the KIRC breakdown →