DRC7

Across TCGA pan-cancer cohorts, DRC7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DRC7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DRC7 RNA is repressed in tumor relative to normal tissue. In most cancer types DRC7 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and LUSC are the cancer types where DRC7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DRC7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−1.140	<.001	11	view →
LUAD	Female	All	−0.991	<.001	9	view →
LUSC	Male	II,III,IV	−1.417	<.001	8	view →
KIRC	Male	II,III,IV	−0.448	<.001	8	view →
THCA	Female	All	−0.212	<.001	8	view →
KIRP	Male	All	+1.219	<.001	7	view →
LIHC	Male	II,III,IV	+0.449	<.001	7	view →
BRCA	All	All	+0.119	.001	4	view →
READ	Male	All	+0.053	.002	4	view →
CHOL	All	All	+0.916	.006	2	view →
ESCA	All	II,III,IV	+0.185	<.001	2	view →
STAD	All	All	+0.166	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DRC7–KICH

Open the KICH breakdown →