DPYS

Across TCGA cell cohorts, DPYS mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DPYS-associated genes across cancer lineages are KRTAP7-1, OPN5, and OR14K1. Each is linked with DPYS in more than 1 cancer types. Because this analysis shows association rather than direction, both DPYS-to-partner and partner-to-DPYS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP7-1 grouped by DPYS-low versus DPYS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPYS→partner) and Y-score (partner→DPYS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KRTAP7-1 →	+0.048	+4.437	<.001	.004	3	2
LARGE_INTESTINE	OPN5 →	+0.022	+3.793	.002	.007	3	1
LARGE_INTESTINE	OR14K1 →	+0.081	+4.437	<.001	.004	3	1
LARGE_INTESTINE	CENPVL3 →	+0.257	+3.920	<.001	.005	3	1
LARGE_INTESTINE	F11 →	+0.070	+4.882	<.001	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	DAZ3 →	+0.256	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

KRTAP7-1 by DPYS expression — LARGE_INTESTINE

Explore this box plot interactively →