DPYS

Across TCGA pan-cancer cohorts, DPYS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DPYS’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DPYS RNA is repressed in tumor relative to normal tissue. In most cancer types DPYS is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and KIRP are the cancer types where DPYS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DPYS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−0.441	<.001	11	view →
KICH	Male	II,III,IV	−5.177	<.001	9	view →
KIRP	All	III,IV	−3.252	<.001	9	view →
LIHC	Female	All	−2.679	<.001	9	view →
LUSC	Male	II,III,IV	−0.571	<.001	8	view →
BRCA	Female	II,III,IV	−0.351	<.001	6	view →
CHOL	Female	All	−7.710	<.001	5	view →
BLCA	All	III,IV	−0.081	.040	3	view →
PRAD	All	All	−0.873	.002	2	view →
PAAD	Male	All	−0.390	.041	2	view →
UCEC	All	All	−0.180	.037	2	view →
THCA	All	All	+0.038	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DPYS–LUAD

Open the LUAD breakdown →