DPP8

Across TCGA patient cohorts, DPP8 mutation is significantly associated with the RNA expression of many other genes, with 2,586 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPP8-associated genes across cancer lineages are MRPS18BP2, FAXDC2, and RNU6-1018P. Each is linked with DPP8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DPP8-to-partner and partner-to-DPP8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS18BP2 grouped by DPP8-low versus DPP8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPP8→partner) and Y-score (partner→DPP8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPS18BP2 →	+0.252	+3.003	<.001	.003	3	3
UCEC	FAXDC2 →	-0.616	-3.796	<.001	<.001	3	3
THCA	RNU6-1018P →	+0.218	+7.962	<.001	.007	3	2
CESC	LDHAP1 →	+0.104	+3.754	<.001	.006	3	2
UCEC	CENPM →	+0.516	+3.098	.002	<.001	3	2
UCEC	MCAT →	+0.303	+1.949	.006	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,586 associations by consensus.

MRPS18BP2 by DPP8 expression — COAD

Explore this box plot interactively →