DPH1

Across TCGA patient cohorts, DPH1 mutation is significantly associated with the RNA expression of many other genes, with 2,601 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DPH1-associated genes across cancer lineages are RN7SL567P, RNU6-521P, and RN7SL248P. Each is linked with DPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DPH1-to-partner and partner-to-DPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL567P grouped by DPH1-low versus DPH1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DPH1→partner) and Y-score (partner→DPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL567P →	+0.202	+5.093	<.001	.008	3	2
BLCA	RNU6-521P →	+0.466	+4.618	<.001	.005	3	2
UCEC	RN7SL248P →	+0.056	+3.059	<.001	.005	3	2
BLCA	RNU6-1263P →	+0.564	+3.506	<.001	.005	3	2
CESC	CYCSP27 →	+0.148	+4.705	<.001	.003	3	2
UCEC	RN7SL134P →	+0.091	+2.184	.006	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,601 associations by consensus.

RN7SL567P by DPH1 expression — LUSC

Explore this box plot interactively →