DPH1

Across TCGA pan-cancer cohorts, DPH1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DPH1 data layer compared with 7 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in pancreatic adenocarcinoma (PAAD), where higher DPH1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DPH1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and READ show a favorable association.

PAAD, READ, and LUSC are the cancer types where DPH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PAAD	OS	Tertile	All	0.586	0.269	<.001	60	view →
READ	OS	Tertile	All	1.000	0.442	.001	51	view →
LUSC	DFS	Median	III,IV	0.512	0.914	.006	44	view →
BRCA	DFS	Quartile	III,IV	0.955	0.792	<.001	36	view →
SCLC	OS	Tertile	All	0.835	0.567	.001	31	view →
CHOL	OS	Quartile	All	0.348	0.903	.009	15	view →
MESO	DFS	Tertile	IV	0.231	0.679	.011	15	view →
BLCA	DFS	Tertile	All	0.228	0.480	.010	15	view →
ESCA	DFS	Quartile	All	1.000	0.401	.009	12	view →
KIRC	DFS	Median	IV	0.222	0.490	.003	9	view →
HNSC	OS	Median	All	0.624	0.787	.009	9	view →
LUAD	DFS	Median	III,IV	0.251	0.540	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DPH1–PAAD (OS)

Open the PAAD breakdown →