DOP1A

Across TCGA cell cohorts, DOP1A mutation is significantly associated with the RNA expression of many other genes, with 1,230 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOP1A-associated genes across cancer lineages are URAD, SRF, and HELB. Each is linked with DOP1A in more than 1 cancer types. Because this analysis shows association rather than direction, both DOP1A-to-partner and partner-to-DOP1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, URAD grouped by DOP1A-low versus DOP1A-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOP1A→partner) and Y-score (partner→DOP1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	URAD →	+0.056	+4.371	<.001	.005	3	2
LARGE_INTESTINE	SRF →	+0.428	+2.244	.004	.003	3	2
LARGE_INTESTINE	HELB →	+0.386	+3.459	.001	.001	3	2
LARGE_INTESTINE	SLBP →	+0.432	+2.244	.006	.003	3	2
LARGE_INTESTINE	KCNRG →	+0.433	+2.158	.001	.004	3	2
LARGE_INTESTINE	RXRB →	+0.498	+3.321	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,230 associations by consensus.

URAD by DOP1A expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →