DOP1A

Across TCGA pan-cancer cohorts, DOP1A RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of DOP1A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where DOP1A RNA is repressed in tumor relative to normal tissue. In most cancer types DOP1A is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, BRCA, and LUAD are the cancer types where DOP1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOP1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.295	<.001	10	view →
BRCA	All	III,IV	−0.580	<.001	6	view →
LUAD	Female	II,III,IV	−0.577	.006	5	view →
LUSC	All	II,III,IV	−0.527	<.001	4	view →
THCA	All	II,III,IV	−0.530	.008	3	view →
CHOL	All	All	+0.787	.012	2	view →
UCEC	All	All	−0.542	<.001	2	view →
COAD	Female	All	−0.397	.022	2	view →
PRAD	All	All	−0.345	.007	2	view →
ESCA	Female	All	+0.833	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

DOP1A–KICH

Open the KICH breakdown →