DOLK

Across TCGA patient cohorts, DOLK mutation is significantly associated with the RNA expression of many other genes, with 3,126 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOLK-associated genes across cancer lineages are IFNA2, OR7A15P, and FRG2. Each is linked with DOLK in more than 2 cancer types. Because this analysis shows association rather than direction, both DOLK-to-partner and partner-to-DOLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA2 grouped by DOLK-low versus DOLK-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOLK→partner) and Y-score (partner→DOLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	IFNA2 →	+0.038	+5.010	.008	.009	3	3
BLCA	OR7A15P →	+0.038	+3.681	.007	.005	3	2
UCEC	FRG2 →	+0.196	+1.871	.002	.002	3	2
UCEC	C7orf66 →	+0.283	+1.841	<.001	.003	3	2
UCEC	SNORD90 →	+0.239	+1.892	<.001	.005	3	2
COAD	RNU6ATAC30P →	+0.356	+4.893	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,126 associations by consensus.

IFNA2 by DOLK expression — CESC

Explore this box plot interactively →