DOLK

Across TCGA pan-cancer cohorts, DOLK RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DOLK data layer compared with 4 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DOLK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DOLK expression acts as an unfavorable survival marker, although some lineages such as KIRC and THCA show a favorable association.

BLCA, UVM, and ACC are the cancer types where DOLK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	II,III,IV	0.601	0.788	<.001	115	view →
UVM	DFS	Tertile	II,III,IV	0.310	0.804	<.001	95	view →
ACC	DFS	Median	All	0.253	0.642	<.001	60	view →
LIHC	DFS	Quartile	All	0.356	0.559	<.001	53	view →
KIRC	DFS	Tertile	All	0.740	0.531	<.001	53	view →
HNSC	OS	Tertile	All	0.298	0.449	.005	51	view →
THCA	OS	Tertile	III,IV	1.000	0.679	<.001	47	view →
UCEC	DFS	Quartile	III,IV	0.829	0.431	.001	46	view →
SKCM	OS	Median	All	0.245	0.414	<.001	30	view →
SARC	OS	Median	All	0.816	0.640	.002	28	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	24	view →
LAML	DFS	Quartile	All	0.374	0.676	.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DOLK–BLCA (OS)

Open the BLCA breakdown →