DOLK

Across TCGA pan-cancer cohorts, DOLK RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DOLK’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DOLK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DOLK is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, COAD, and LIHC are the cancer types where DOLK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOLK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.017	<.001	12	view →
COAD	Female	II,III,IV	+0.705	<.001	11	view →
LIHC	Female	II,III,IV	+1.336	<.001	9	view →
STAD	Male	II,III,IV	+1.119	<.001	8	view →
KICH	Male	All	−1.046	<.001	7	view →
BRCA	All	III,IV	+0.613	<.001	6	view →
BLCA	All	All	+0.523	<.001	6	view →
THCA	Female	All	+0.342	<.001	5	view →
KIRP	Male	II,III,IV	+0.596	.001	4	view →
CHOL	All	All	+1.350	<.001	3	view →
KIRC	Male	II,III,IV	−0.348	.007	3	view →
ESCA	All	All	+0.758	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DOLK–HNSC

Open the HNSC breakdown →