DOLK

Across TCGA patient cohorts, DOLK mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DOLK-associated genes across cancer lineages are A-Raf_pS299, 14-3-3_beta, and eIF4G. Each is linked with DOLK in more than 1 cancer types. Because this analysis shows association rather than direction, both DOLK-to-partner and partner-to-DOLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by DOLK-low versus DOLK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOLK→partner) and Y-score (partner→DOLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.129	-2.700	.004	.006	3	2
UCEC	14-3-3_beta →	-0.082	-2.432	.032	.018	3	1
UCEC	eIF4G →	+0.264	+3.169	.026	.018	3	1
UCEC	ERK2 →	+0.251	+2.807	<.001	.003	3	1
UCEC	JNK_pT183_Y185 →	-0.137	-1.664	.034	.023	3	1
UCEC	JNK2 →	+0.235	+1.594	.002	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

A-Raf_pS299 by DOLK expression — UCEC

Explore this box plot interactively →