DOLK

Across TCGA cell cohorts, DOLK mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DOLK-associated genes across cancer lineages are SOX1, IL5, and MC3R. Each is linked with DOLK in more than 1 cancer types. Because this analysis shows association rather than direction, both DOLK-to-partner and partner-to-DOLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SOX1 grouped by DOLK-low versus DOLK-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOLK→partner) and Y-score (partner→DOLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SOX1 →	+0.386	+3.301	<.001	.001	3	2
BLOOD_Leukemia	IL5 →	+0.180	+3.590	<.001	.007	3	1
BLOOD_Leukemia	MC3R →	+0.008	+3.984	<.001	.006	3	1
BLOOD_Leukemia	NPFFR1 →	+0.009	+2.774	.001	.006	3	1
BLOOD_Leukemia	DIRAS2 →	+0.064	+4.036	<.001	<.001	3	1
BLOOD_Leukemia	SSX3 →	+0.810	+3.561	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

SOX1 by DOLK expression — BLOOD_Leukemia

Explore this box plot interactively →