DOCK8

Across TCGA cell cohorts, DOCK8 mutation is significantly associated with the RNA expression of many other genes, with 1,249 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK8-associated genes across cancer lineages are RELCH, TEX46, and H2AB2. Each is linked with DOCK8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DOCK8-to-partner and partner-to-DOCK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RELCH grouped by DOCK8-low versus DOCK8-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK8→partner) and Y-score (partner→DOCK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RELCH →	+0.680	+3.169	.001	.009	3	3
SOFT_TISSUE	TEX46 →	+0.142	+2.678	<.001	.005	3	2
SOFT_TISSUE	H2AB2 →	+0.209	+2.392	.001	.009	3	2
CNS	C16orf90 →	+0.026	+2.993	<.001	<.001	3	2
CNS	JOSD1 →	+0.482	+3.390	.003	.003	2	3
LARGE_INTESTINE	EP300 →	+0.746	+3.321	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,249 associations by consensus.

RELCH by DOCK8 expression — LARGE_INTESTINE

Explore this box plot interactively →