DOCK8

Across TCGA pan-cancer cohorts, DOCK8 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DOCK8’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DOCK8 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DOCK8 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.

KIRC, LUAD, and LUSC are the cancer types where DOCK8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DOCK8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.438	<.001	12	view →
LUAD	Female	II,III,IV	−1.111	<.001	8	view →
LUSC	Male	All	−1.945	<.001	7	view →
THCA	Female	All	−0.686	<.001	6	view →
BRCA	All	All	−0.462	<.001	6	view →
COAD	Female	All	−0.756	<.001	5	view →
KICH	All	All	+0.829	.012	4	view →
KIRP	All	All	+0.576	.004	2	view →
CHOL	All	All	+0.743	.045	1	view →
HNSC	Male	IV	−0.649	.038	1	view →
STAD	All	All	+0.584	.036	1	view →
LIHC	Male	All	−0.505	.013	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DOCK8–KIRC

Open the KIRC breakdown →