DOCK10

Across TCGA cell cohorts, DOCK10 mutation is significantly associated with the RNA expression of many other genes, with 1,043 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DOCK10-associated genes across cancer lineages are RLN3, GPX5, and CEACAM3. Each is linked with DOCK10 in more than 1 cancer types. Because this analysis shows association rather than direction, both DOCK10-to-partner and partner-to-DOCK10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RLN3 grouped by DOCK10-low versus DOCK10-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOCK10→partner) and Y-score (partner→DOCK10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RLN3 →	+0.041	+5.369	<.001	.004	3	2
LUNG_NSCLC_LUSC	GPX5 →	+0.027	+3.137	<.001	.003	3	2
BLOOD_Lymphoma	CEACAM3 →	+0.078	+3.342	<.001	.008	3	2
BLOOD_Leukemia	ADIG →	+0.010	+3.762	<.001	.007	3	2
BLOOD_Leukemia	MFRP →	+0.133	+3.957	<.001	<.001	3	2
BLOOD_Leukemia	FKBP6 →	+0.088	+2.757	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,043 associations by consensus.

RLN3 by DOCK10 expression — SOFT_TISSUE

Explore this box plot interactively →