DOCK10

Across TCGA pan-cancer cohorts, DOCK10 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated DOCK10 data layer compared with 11 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DOCK10 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DOCK10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

UVM, HNSC, and KIRP are the cancer types where DOCK10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.450	0.796	<.001	119	view →
HNSC	DFS	Median	All	0.705	0.542	<.001	119	view →
KIRP	DFS	Quartile	All	0.757	0.935	.001	107	view →
KIRC	DFS	Tertile	All	0.895	0.731	.002	66	view →
ACC	DFS	Median	All	0.572	0.870	.002	42	view →
BRCA	DFS	Tertile	III,IV	0.866	0.695	.002	32	view →
SKCM	OS	Quartile	All	0.388	0.225	<.001	32	view →
PAAD	DFS	Median	All	0.422	0.299	.009	22	view →
SCLC	DFS	Quartile	II,III,IV	0.729	0.330	.008	19	view →
UCEC	DFS	Median	III,IV	0.674	0.460	.021	16	view →
CHOL	DFS	Tertile	All	0.623	0.210	.047	9	view →
UCS	DFS	Median	All	0.383	0.178	.030	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

DOCK10–UVM (OS)

Open the UVM breakdown →