DNTTIP2

Across TCGA patient cohorts, DNTTIP2 mutation is significantly associated with the RNA expression of many other genes, with 2,744 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNTTIP2-associated genes across cancer lineages are TRDJ2, MIR1273H, and STSP1. Each is linked with DNTTIP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNTTIP2-to-partner and partner-to-DNTTIP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDJ2 grouped by DNTTIP2-low versus DNTTIP2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTTIP2→partner) and Y-score (partner→DNTTIP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TRDJ2 →	+1.081	+4.621	<.001	.004	3	3
CESC	MIR1273H →	+0.320	+5.539	<.001	.004	3	2
BRCA	STSP1 →	+0.031	+6.342	<.001	<.001	3	2
UCEC	RNU4-58P →	+0.155	+2.207	.004	.006	3	2
UCEC	RNU6-668P →	+0.197	+2.449	<.001	.007	3	2
UCEC	MIR1298 →	+0.057	+4.606	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,744 associations by consensus.

TRDJ2 by DNTTIP2 expression — LUSC

Explore this box plot interactively →