DNTTIP2

Across TCGA pan-cancer cohorts, DNTTIP2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DNTTIP2’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where DNTTIP2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNTTIP2 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LIHC, THCA, and HNSC are the cancer types where DNTTIP2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNTTIP2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	II,III,IV	+1.181	<.001	9	view →
THCA	Male	III,IV	−0.479	<.001	9	view →
HNSC	All	III,IV	+0.457	<.001	9	view →
KICH	Female	II,III,IV	−1.521	<.001	8	view →
KIRC	All	All	+0.292	<.001	6	view →
CHOL	Male	All	+1.863	<.001	5	view →
LUSC	Male	All	+0.442	<.001	4	view →
STAD	All	II,III,IV	+0.422	.014	4	view →
COAD	Male	All	+0.360	.004	4	view →
LUAD	All	All	+0.229	.003	4	view →
PAAD	Male	All	+0.195	.003	2	view →
ESCA	All	All	+0.631	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DNTTIP2–LIHC

Open the LIHC breakdown →