DNPH1

Across TCGA patient cohorts, DNPH1 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNPH1-associated genes across cancer lineages are RNU6-830P, RNU6-365P, and RNA5SP454. Each is linked with DNPH1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNPH1-to-partner and partner-to-DNPH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-830P grouped by DNPH1-low versus DNPH1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNPH1→partner) and Y-score (partner→DNPH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-830P →	+0.393	+7.816	<.001	.008	3	1
SKCM	RNU6-365P →	+0.396	+7.816	<.001	.008	3	1
SKCM	RNA5SP454 →	+0.342	+7.816	<.001	.008	3	1
BLCA	RNU6-673P →	+0.558	+5.106	<.001	.008	3	1
BLCA	RNU6-95P →	+0.557	+5.685	<.001	.003	3	1
UCEC	MIR3145 →	+0.719	+3.393	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

RNU6-830P by DNPH1 expression — SKCM

Explore this box plot interactively →