DNPH1

Across TCGA pan-cancer cohorts, DNPH1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DNPH1 data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher DNPH1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNPH1 expression acts as an unfavorable survival marker, although some lineages such as OV and MESO show a favorable association.

UVM, UCS, and COAD are the cancer types where DNPH1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.433	0.846	<.001	120	view →
UCS	DFS	Quartile	III,IV	0.178	0.699	<.001	66	view →
COAD	DFS	Quartile	III,IV	0.388	0.714	<.001	39	view →
LAML	DFS	Median	All	0.417	0.733	.001	34	view →
OV	OS	Quartile	All	0.375	0.272	.010	32	view →
THCA	DFS	Quartile	IV	0.403	0.803	.008	31	view →
MESO	OS	Tertile	All	0.487	0.291	.013	22	view →
KIRC	DFS	Median	IV	0.484	0.229	.005	20	view →
KIRP	DFS	Quartile	II,III,IV	0.859	0.184	.039	18	view →
PRAD	DFS	Tertile	All	0.911	0.972	.007	18	view →
BLCA	DFS	Tertile	III,IV	0.307	0.098	.024	16	view →
ACC	DFS	Quartile	All	0.228	0.558	.012	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DNPH1–UVM (DFS)

Open the UVM breakdown →