DNMT3B

Across TCGA patient cohorts, DNMT3B protein abundance is significantly associated with the protein abundance of many other proteins, with 4,804 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DNMT3B-associated proteins across cancer lineages are HMGA1_S44, NCAPD2, and NCAPH. Each is linked with DNMT3B in more than 2 cancer types. Because this analysis shows association rather than direction, both DNMT3B-to-partner and partner-to-DNMT3B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNMT3B versus HMGA1_S44 in BRCA, with a Pearson correlation of 0.82.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3B→partner) and Y-score (partner→DNMT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HMGA1_S44 →	+1.904	+1.026	<.001	<.001	3	3
UCEC	NCAPD2 →	+0.760	+0.507	<.001	<.001	3	3
UCEC	NCAPH →	+0.826	+0.556	<.001	<.001	3	3
UCEC	NDC80 →	+0.750	+0.552	<.001	<.001	3	3
UCEC	ARMC1_S246 →	+1.034	+0.789	.001	.001	3	2
LSCC	ASXL2_S562 →	+0.651	+1.271	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,804 associations by consensus.

DNMT3B vs HMGA1_S44 — BRCA

Explore this scatter interactively →