DNMT3B

Across TCGA pan-cancer cohorts, DNMT3B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of DNMT3B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DNMT3B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNMT3B is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where DNMT3B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNMT3B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.833	<.001	12	view →
BLCA	Male	III,IV	+2.278	<.001	11	view →
COAD	Male	II,III,IV	+1.104	<.001	10	view →
KIRP	All	II,III,IV	+1.641	<.001	9	view →
LUAD	Male	III,IV	+1.383	<.001	9	view →
UCEC	All	III,IV	+2.595	<.001	8	view →
LUSC	Male	II,III,IV	+2.254	<.001	8	view →
STAD	Male	II,III,IV	+1.518	<.001	8	view →
LIHC	Female	II,III,IV	+1.025	<.001	8	view →
THCA	Male	All	−0.604	<.001	8	view →
READ	All	All	+0.921	.001	7	view →
BRCA	All	III,IV	+0.959	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

DNMT3B–HNSC

Open the HNSC breakdown →