DNMT3B

Across TCGA cell cohorts, DNMT3B mutation is significantly associated with the RNA expression of many other genes, with 412 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNMT3B-associated genes across cancer lineages are KRT71, FAM47B, and GRIFIN. Each is linked with DNMT3B in more than 1 cancer types. Because this analysis shows association rather than direction, both DNMT3B-to-partner and partner-to-DNMT3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT71 grouped by DNMT3B-low versus DNMT3B-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3B→partner) and Y-score (partner→DNMT3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KRT71 →	+0.009	+4.643	<.001	.005	3	1
OVARY	FAM47B →	+0.012	+5.196	<.001	.005	3	1
OVARY	GRIFIN →	+0.035	+5.196	<.001	.005	3	1
BLOOD_Leukemia	TACR3 →	+0.035	+5.060	<.001	.001	3	1
BLOOD_Leukemia	GUCA2A →	+0.039	+4.969	<.001	.003	3	1
BLOOD_Leukemia	KRTAP7-1 →	+0.071	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 412 associations by consensus.

KRT71 by DNMT3B expression — BLOOD_Lymphoma

Explore this box plot interactively →