DNMT3A

Across TCGA cell cohorts, DNMT3A mutation is significantly associated with the RNA expression of many other genes, with 422 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DNMT3A-associated genes across cancer lineages are PIGL, NFYB, and PF4V1. Each is linked with DNMT3A in more than 1 cancer types. Because this analysis shows association rather than direction, both DNMT3A-to-partner and partner-to-DNMT3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIGL grouped by DNMT3A-low versus DNMT3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3A→partner) and Y-score (partner→DNMT3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PIGL →	+0.632	+3.628	.007	<.001	3	2
LARGE_INTESTINE	NFYB →	+0.447	+3.169	.002	.009	3	2
BLOOD_Leukemia	PF4V1 →	+0.078	+2.802	<.001	.007	3	2
BLOOD_Leukemia	GK5 →	+0.714	+3.366	.002	.002	3	2
BLOOD_Leukemia	MRGPRX3 →	+0.013	+2.146	<.001	.009	3	2
BLOOD_Leukemia	C15orf61 →	+0.355	+2.489	.007	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 422 associations by consensus.

PIGL by DNMT3A expression — LARGE_INTESTINE

Explore this box plot interactively →