DNMT3A

Across TCGA pan-cancer cohorts, DNMT3A RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated DNMT3A data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher DNMT3A RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNMT3A expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

ACC, UCS, and LIHC are the cancer types where DNMT3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.361	0.889	<.001	139	view →
UCS	OS	Tertile	II,III,IV	0.712	0.181	<.001	120	view →
LIHC	OS	Quartile	All	0.532	0.765	<.001	95	view →
MESO	OS	Median	All	0.246	0.513	<.001	75	view →
LGG	DFS	Median	All	0.633	0.841	<.001	54	view →
SCLC	DFS	Tertile	II,III,IV	0.873	0.139	.006	41	view →
LAML	DFS	Quartile	All	0.526	0.265	.006	34	view →
KICH	DFS	Tertile	III,IV	0.326	1.000	.002	34	view →
UVM	OS	Median	III,IV	0.296	1.000	.005	32	view →
PAAD	OS	Tertile	All	0.566	0.359	.005	29	view →
UCEC	DFS	Tertile	All	0.535	0.659	.007	26	view →
KIRC	DFS	Tertile	II,III,IV	0.422	0.638	.019	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

DNMT3A–ACC (OS)

Open the ACC breakdown →