DNMBP

Across TCGA cell cohorts, DNMBP mutation is significantly associated with the RNA expression of many other genes, with 301 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNMBP-associated genes across cancer lineages are FTMT, IL27, and MFRP. Each is linked with DNMBP in more than 1 cancer types. Because this analysis shows association rather than direction, both DNMBP-to-partner and partner-to-DNMBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTMT grouped by DNMBP-low versus DNMBP-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMBP→partner) and Y-score (partner→DNMBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	FTMT →	+0.043	+3.977	<.001	.007	3	1
SOFT_TISSUE	IL27 →	+0.027	+3.297	<.001	.008	3	1
SKIN	MFRP →	+0.014	+3.684	<.001	.006	3	1
STOMACH	CCDC195 →	+0.198	+3.794	<.001	.003	3	1
STOMACH	FMO2 →	+0.294	+3.632	.001	.009	3	1
LARGE_INTESTINE	SAMM50 →	+0.509	+3.064	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 301 associations by consensus.

FTMT by DNMBP expression — SOFT_TISSUE

Explore this box plot interactively →