DND1

Across TCGA cell cohorts, DND1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DND1-associated genes across cancer lineages are MYBPC3, BPIFB3, and CYP4F8. Each is linked with DND1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DND1-to-partner and partner-to-DND1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYBPC3 grouped by DND1-low versus DND1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DND1→partner) and Y-score (partner→DND1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MYBPC3 →	+0.016	+4.273	<.001	.006	3	1
SKIN	BPIFB3 →	+0.022	+5.022	<.001	.002	3	1
SKIN	CYP4F8 →	+0.037	+5.217	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.102	+3.155	.002	.008	3	1
BLOOD_Leukemia	COL20A1 →	+0.695	+3.781	<.001	.004	3	1
BLOOD_Leukemia	SLC32A1 →	+0.567	+3.223	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MYBPC3 by DND1 expression — SKIN

Explore this box plot interactively →