DNASE1L1

Across TCGA cell cohorts, DNASE1L1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DNASE1L1-associated genes across cancer lineages are GPR101, ASB17, and LRRC53. Each is linked with DNASE1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNASE1L1-to-partner and partner-to-DNASE1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR101 grouped by DNASE1L1-low versus DNASE1L1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE1L1→partner) and Y-score (partner→DNASE1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR101 →	+0.015	+4.887	<.001	.009	3	2
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1
LUNG_NSCLC_LUAD	LRRC53 →	+0.012	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	CLRN1 →	+0.033	+6.266	<.001	<.001	3	1
LARGE_INTESTINE	KCNG4 →	+0.006	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

GPR101 by DNASE1L1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →