DNAJC27

Across TCGA patient cohorts, DNAJC27 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNAJC27-associated genes across cancer lineages are Ku80, MEK1, and Notch1. Each is linked with DNAJC27 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNAJC27-to-partner and partner-to-DNAJC27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by DNAJC27-low versus DNAJC27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC27→partner) and Y-score (partner→DNAJC27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.326	+2.820	.016	.035	3	1
UCEC	MEK1 →	+0.540	+3.000	.010	.036	3	1
UCEC	Notch1 →	+0.174	+3.000	.032	.037	3	1
UCEC	VHL →	-1.387	-3.000	<.001	.037	3	1
UCEC	ASNS →	+0.552	+3.000	.008	.036	3	1
UCEC	Collagen-VI →	-0.266	-3.000	.025	.037	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Ku80 by DNAJC27 expression — UCEC

Explore this box plot interactively →