DNAJC27

Across TCGA pan-cancer cohorts, DNAJC27 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DNAJC27’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where DNAJC27 RNA is repressed in tumor relative to normal tissue. In most cancer types DNAJC27 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

THCA, LUAD, and UCEC are the cancer types where DNAJC27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNAJC27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.181	<.001	11	view →
LUAD	Female	II,III,IV	−0.906	<.001	9	view →
UCEC	All	All	−0.962	<.001	8	view →
BLCA	Male	All	−0.630	.005	8	view →
KIRC	Male	III,IV	−0.573	<.001	8	view →
KICH	Male	All	−1.181	<.001	7	view →
BRCA	All	III,IV	−0.565	<.001	6	view →
LUSC	All	II,III,IV	−0.538	<.001	6	view →
LIHC	All	II,III,IV	+0.330	.001	6	view →
CHOL	All	All	+1.178	<.001	5	view →
KIRP	Male	All	−0.575	<.001	4	view →
PRAD	All	All	−0.380	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DNAJC27–THCA

Open the THCA breakdown →