DNAJC25-GNG10

Across TCGA patient cohorts, DNAJC25-GNG10 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,594 significant associations in total. THCA shows the largest number of these associations.

The most reproducible DNAJC25-GNG10-associated GO terms across cancer lineages are Negative regulation of hippo signaling, Telomere tethering at nuclear periphery, and Positive regulation of isotype switching to IgA isotypes. Each is linked with DNAJC25-GNG10 in more than 8 cancer types. Because this analysis shows association rather than direction, both DNAJC25-GNG10-to-partner and partner-to-DNAJC25-GNG10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hippo signaling grouped by DNAJC25-GNG10-low versus DNAJC25-GNG10-high in UCS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNAJC25-GNG10→partner) and Y-score (partner→DNAJC25-GNG10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCS	Negative regulation of hippo signaling →	+0.042	+0.035	.004	.002	1	9
THYM	Telomere tethering at nuclear periphery →	+0.079	+0.014	.001	.001	3	7
OV	Positive regulation of isotype switching to IgA isotypes →	+0.031	+0.021	<.001	<.001	2	8
READ	Regulation of chromosome condensation →	+0.035	+0.032	.002	.005	3	7
UVM	Cellular response to manganese ion →	+0.036	+0.019	.009	.005	3	6
UCS	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.034	+0.044	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,594 associations by consensus.

Negative regulation of hippo signaling by DNAJC25-GNG10 expression — UCS

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