Across TCGA pan-cancer cohorts, DNAJC25-GNG10 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of DNAJC25-GNG10’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where DNAJC25-GNG10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DNAJC25-GNG10 is over-expressed in tumor.
LUAD, STAD, and LIHC are the cancer types where DNAJC25-GNG10 tumor–normal differential expression is most reproducible.